From 2011 to 2018, Lelling said wealthy parents made about $25 million in payments to guarantee their children's admission to elite schools, and Federal Bureau of Investigation agents wiretapped phone calls involving some of the parents and a cooperating witness.
The scheme involved coaches in soccer, tennis, volleyball and crew taking bribes to put students on lists of recruited athletes, despite any experience, so the students faced a lower standard of admission.
"These parents are a catalog of wealth and privilege", U.S. Attorney Andrew Lelling said.
Records on file in court say several defendants are facing either racketeering or mail fraud charges.
Center, 54, is charged with conspiracy to commit mail fraud and honest services mail fraud. Another actress, Lori Loughlin, best known for starring in sitcom Full House, was also indicted.
Officials say parents spent anywhere from $200,000 to $6.5 million to guarantee their children's admission.
Federal court records unsealed Tuesday in Boston name 50 people who have been indicted as part of the nationwide scheme, according to a release from the U.S. Attorney's Office in MA.
Macy showed his support for wife Felicity Huffman on Tuesday at a Los Angeles courthouse. Huffman allegedly paid $15,000 for her oldest daughter and began the process for her second child but ultimately abandoned the plan because she was anxious a fixed score would "set off alarm bells".
Huffman is married to actor William H. Macy.
A rep for Huffman did not return Fox News' repeated requests for comment.
Athletic coaches from Yale, Stanford, USC, and Georgetown, among others, were also implicated as well as parents and exam administrators, federal prosecutors said.
Singer also fabricated "impressive athletic profiles" for applicants to apply as athletes - knowing full well that universities have allocated slots for students who play sports.
In some cases, college entrance exam administrators were paid off to allow a Florida man take the tests for the children of Singer's clients. Among the colleges named in the indictment are Yale University, Stanford University, Georgetown and the University of Southern California.