Marshall died in her home in Hollywood Hills on December 17 after suffering from complications from diabetes, reported TMZ, which broke the story on December 18. Her publicist told the NY Daily News that "she passed away from complications from diabetes". She also had a recurring role on the sitcom "The Odd Couple", as Myrna Turner, secretary to sportswriter Oscar Madison (played by Jack Klugman). Years after wrapping the show, she turned to directing, enjoying her first unqualified success directing Tom Hanks in "Big" (1988), which grossed more than $100 million.
Marshall had reportedly been diagnosed with lung cancer in 2010 that had metastasized to her brain, but she later revealed in 2012 that she was in remission.
Reiner paid tribute to his former wife, saying on Twitter: "I loved Penny. Watch some old Laverne and Shirley to see why her brother Garry insisted on casting her. Comedy gold, she was".
Marshall, whose real name was Carole Marshall, grew up in the Bronx.
Describing her upbringing, Marshall, who wrote a memoir titled "My Mother Was Nuts", once said, "you had to form a sense of humor or else you'd kill yourself".
She also had a great sense of humor.
And so the actress chose to step behind the camera, an unlikely career move that provided a successful second act to her career. After a series of jobs including a stint as a choreographer in Albuquerque, she left for Los Angeles in 1967, according to the Hollywood Reporter. Our deepest condolences go out to her family and friends. A celebration of life ceremony will be held at a later date.