Officials at Fly Jamaica said flight OJ256, which was headed to Toronto, had to make an emergency landing because of a technical problem.
In July 2011, a Boeing 737-800 aircraft belonging to Trinidad-based Caribbean Airlines crashed at the same airport after landing too far down the runway and running out of braking space, injuring several people.
In a statement this morning, the airline says it believes all 118 passengers and eight crew were safe following the crash in Georgetown.
Flight Alerts, a Twitter account monitoring aircraft, reported the plane overshot the runway and crashed into a fence.
The Boeing 757, carrying 126 people, including two infants, returned after experiencing hydraulic problems.
St. Lucia News also there were 82 Canadians on board the flight, which was Toronto-bound.
The airport said on its Facebook page that the injuries were considered to be non-life-threatening.
Guyana's public infrastructure minister, David Patterson, planned to provide a detailed report on the incident Friday. However, he noted that the extended runway, though not opened at the time, served to cushion the impact.
Amid an investigation into what caused a brand-new 737 Max jet to crash in Indonesia, another jet produced by USA aerospace and defense company Boeing crash landed in Guyana.
Bedessee said takeoff had been delayed by about 45 minutes because one of the left-side doors had "not closed properly" and a maintenance crew was called to fix the problem.
A spokesperson for Fly Jamaica said it is providing local assistance for its passengers and "will furhter release information as soon as it is available".