Los Blancos continue to struggle in front of the goal without their record-breaking scorer but Ronaldo insisted that he has no business with the ongoing on-pitch crisis of Real Madrid.
He told a press conference, as reported in the Spanish media: "I am looking at the situation the same as ever, I am carrying out my day-to-day as usual and that is what is under our control".
Another defeat for the European champions at the weekend - this time at home to Levante - has seen strong speculation that Lopetegui could be sacked by the end of Monday.
Lopetegui has been defiant over questions about his future, saying: "What I've learned about this club is to fight, that is the DNA of this club".
However, while they have not been on opposite sides particularly often over the past decade, an in-form Ronaldo will surely be confident of improving a dismal record of one goal in 14 games against his compatriot, who has lost just one of five meetings with Juve as a coach.
"It has been assumed as done and dusted from what I have read but what I have done is analyse and prepare for the rival, I am not thinking of anything else which is my responsibility", said Lopetegui.
"It's all right. You cannot cry", said Ronaldo. "I will be the coach tomorrow".
Plzen travel to the Spanish capital second in their domestic league, but without much expectation. The Czech champions will have a tough task facing Los Blancos in Madrid having lost the last time out to Roma on the road in the Champions League by a 5-0 score line.
The Italian was linked with Real Madrid in the summer following the departure of Zinedine Zidane, however he was still contracted to Chelsea, so the footballing superpower instead opted for the then Spain manager Lopetegui, and on the basis of the Spaniard's opening 12 games it's proved to be a poor decision.
Hazard is still longing for a move to Real Madrid, the team in which he has always dreamed of playing for.