Wolves equalised at Old Trafford on Saturday after Pogba was easily dispossessed in the centre-circle.
The only other Premier League side beaten by lower-league opposition on Wednesday was Burnley which lost 2-1 to third-tier side Burton.
It was therefore a surprise when Pogba was handed the captain's armband for the opening-weekend 2-1 win over Leicester City as a stand-in for regular skipper Antonio Valencia.
Marcus Rashford is out as he serves the final game of a three-match suspension.
The two then appear to have an awkward exchange, with Pogba's facial expressions indicating that he is not happy at, or at least confused by whatever is being said.
They added that while efforts had been made on both sides in the time that has passed since - with Mourinho making the World Cup victor captain - the relationship has ultimately failed to recover. You will find Jose Mourinho's players being managers all over the place because he has been so successful in his career.
Sky Sports News' cameras captured the duo's clash, with Pogba staring fiercely at Mourinho, who was heard saying "Get out" at one point to the 25-year-old midfielder.
"To go down early at Old Trafford and play as well as they did was superb". Barcelona have been heavily linked with a move for the player, while both Paris Saint-Germain and former club Juventus are interested too.
The roller coaster ride that is Manchester United under Jose Mourinho hasn't stopped just yet.
"Manchester United have had some good away results but suddenly they're not able to win at home".
In spite of him slowly losing support in the dressing room, United's high command is reportedly backing Mourinho to guide the team out of a poor run of form.
Mourinho conceded that after the game that his team failed to match Derby's intensity but Macari believes that shouldn't be an excuse for any Manchester United player or team.