The 1998 Australian Open was the last grand slam where Serena and Venus met as early as the third round.
Serena added, "I never root against her, no matter what".
So when it came to the US Open, everyone expected her to go back to "traditional" tennis gear but not Serena.
Both sisters were asked after their wins about playing each other, and each of them delivered with some amusing quotes.
A storm erupted after French player Alize Cornet was given a warning for quickly changing her shirt at the US Open on Tuesday after realising she had put it on back to front. I feel like throughout our career, we have pushed each other to be the best that we can be, and be Venus and Serena Williams'.
No. 16-seed Venus punched her ticket to the duel earlier in the day by fending off Camila Giorgi 6-4, 7-5 at Louis Armstrong Stadium. "I think they have always played really good matches and super competitive".
Serena could root without conflict during last year's U.S. Open - the first without her since 2010 - when Venus reached the semifinals for the first time since 2010, only to be ousted in three sets by eventual champion Sloane Stephens.
Serena wore this Virgil Abloh tutu during the first round of the US Open on Monday - just days after Bernard Giudicelli's interview made headlines. "I'm going to get the information first and then we see if we make a revolution or not, '" said the bemused French player.
Stephens triumphed after 2 hours and 46 minutes on Arthur Ashe Stadium and will next face two-time Australian Open champion and former world number one Victoria Azarenka. "I think we're used to it now".
"I was happy with a lot of things".
Medvedev said there were no hard feelings but admitted to Russian media on Wednesday: "He did block me on Instagram".
Meanwhile, Spanish 12th seed Garbine Muguruza succumbed to unseeded Karolina Muchova of the Czech Republic who recovered from a set down to win 3-6 6-4 6-4 to book a third round clash with Australian Ashleigh Barty.