Aguero also scored two goals in City's 2-0 win over Chelsea in the Community Shield.
Aguero then completed his hat-trick in the 76th minute with a clipped finish at the near post, following another cross from Mendy.
Gabriel Jesus added a second seven minutes later with a crisp low strike from the edge of the area, before Aguero pounced on a Hamer error to stab in his second soon after.
The documentary series, titled All or Nothing: Manchester City, was released on Friday and was met with glowing reviews by those looking to get a glimpse into the reality of being a Premier League footballer.
The opening goal of the game arrived from a familiar source as Aguero wriggled free after a wonderful ball over the top from City's goalkeeper Ederson.
"Manchester City can confirm Kevin De Bruyne has suffered a lateral collateral ligament (LCL) lesion in his right knee", a club statement read.
Last season's success was built on two morale-boosting opening victories albeit the opposition was entirely different - Crystal Palace during Frank de Boer's disastrous brief spell in charge and fellow promoted side Newcastle United. You can probably already pencil them in for 2020 and 2021 such is the quality of this squad of multi-millionaires, who work, rest and play like they are chasing their next meal. Aguero also surpassed Robin Van Persie in the Premier League all-time goalscorer list, and the City hero sits on 146 goals, and is second to Thierry Henry in the highest non-British scorer in the English top-flight.
While the loss of such a player would be a blow to most clubs, City have more depth than most thanks to their Abu Dhabi owners spending generously on players.
City granted the people behind "All Or Nothing", an Amazon franchise who has worked with New Zealand rugby and National Football League teams in the past, access to the inner workings of Pep Guardiola's side for a series that was released yesterday.