The reigning world champion annihilated the MotoGP field to win the Red Bull Grand Prix of the Americas to his sixth consecutive victory at the Austin circuit.
"I didn't have confidence to battle, so I pushed from the beginning and tried to open a gap".
Having been demoted to fourth place on the grid from pole for blocking Maverick Vinales in qualifying, Marquez leapt to second into Turn 1 as Andrea Iannone scorched into an early lead.
Valentino Rossi said he was disappointed to miss out on a podium in Sunday's MotoGP Grand Prix of the Americas, blaming the warm Texas weather for his struggles.
Andrea Dovizioso finished fifth for Ducati and regained the championship lead with 46 points after three races, the Italian is now one clear of Marquez with Vinales third on 41 points. Cal Crutchlow, who was leading the championship with a smashing win at Argentina, is now fourth on the points table. Marquez pulled away lap by lap until his lead reached 7 seconds, and then he coasted in for the win.
Hafizh Syahrinh's fearless race after a heavy crash in the warm-up ended a lap later, crashing at the other end of the front straight, while Karel Abraham also headed to the garage at the same time, still suffering lingering effects from his crash out of Q1 the day before.
The margins among the first four began to blow out through the second half of the race, Dovizioso remaining glued to the back of Zarco in fifth as the pair began to slowly drop Pedrosa.
Marquez continued untroubled up front to clinch victory easily and make it six wins out of six at the Grand Prix of Americas.
Tito Rabat finished eighth for Real Avintia Ducati ahead of the Pramac bike of Jack Miller while Aleix Espargaro rounded out the top ten. I felt a special feeling on the last lap, when I passed in front of Nicky's flag.
Behind him were Pol Espargaro of KTM, LCR Honda's Takaaki Nakagami and Alvaro Bautista of Nieto Ducati taking the last of the points.
Bradley Smith and Scott Redding were next along with Luthi finishing ahead of Crutchlow after he re-mounted - he was also given a 2.7s penalty for cutting a corner.
The MotoGP veteran added that he was looking forward to a different challenge when the competition hits Europe next month for the Spanish GP at the Circuito de Jerez.