South Africa moved into a powerful position despite a fightback by Australia and an injury to Morne Morkel, the fast bowler in his final worldwide, on the third day of the fourth Test at the Wanderers Stadium on Sunday (April 1).
Morkel broke down with a side strain as South Africa toiled in search of a breakthrough, leaving the field two balls into his fourth over of the day.
The scandal-hit tourists, reeling from their ball-tampering scandal and led by new captain Tim Paine, made four changes, including a debut for seamer Chadd Sayers, but having won the toss South Africa had few alarms under cloudy skies.
In response, Australia looked crippled at 6-110, with only Usman Khawaja (53) offering genuine resistence to the hosts' pace and spin attack.
New captain Tim Paine (5*) will resume on the third morning with the impossible task or simply restoring some pride, never mind actually saving the Test. Rain is forecast - it is the only hope the Australians have of avoiding defeat.
South Africa's Aiden Markram celebrates his century.
Saker also gave credit to the home side, who lead the series 2-1. As the day progressed he started to find fluency and he was looking good for his second Test match hundred before he ran out of batting partners when Morne Morkel fell first ball to Pat Cummins, who will begin the second innings on a hat-trick.
Vernon Philander, meanwhile, was the pick of the South African bowlers, finishing the day with figures of 3/17 in 12 to leave him on 198 Test scalps.
The spinner had taken the first two catches himself, but this time the ball was snatched at mid-off by debutant Chadd Sayers.
The other batsmen out were opener Dean Elgar (19), caught off the leading edge from a Lyon delivery for the third time in the series, and Hashim Amla (27), who edged Cummins to Peter Handscombe at second slip.
Temba Bavuma was frustratingly left stranded on 95 in the final Test against Australia at the Wanderers but not before the diminutive right-hander put South Africa on top in their bid to seal the series.
He paid tribute to the quality of South Africa's bowling but added: "Obviously after the week we've had there's a lot of disappointment in the room that we can't put something together".
Burns was the first to go, having a dart at one outside off stump from Kagiso Rabada that was gobbled up by Faf du Plessis at second slip.
Quinton de Kock (7*) joined Bavuma (25*) and the duo took South Africa past the 300 mark and made it through to stumps without any scares, putting on 14 runs in the closing 4.2 overs.