Midfielder Paul Pogba remains a doubt, however, as United try to capitalise on the 0-0 draw in the first leg in Spain.
He has not played since Dec 26.
That is a marked contrast to last season when they finished sixth and had to win the Europa League to earn a place back in the continent's elite club competition.
Moreover, the attractive style implemented by long-time adversary Pep Guardiola is far more in keeping with that United fans are used to seeing than the fare offered up by Mourinho's tactics.
Jose Mourinho teams have never been in the habit of winning beauty contests, but they are rather good at winning football matches.
"Jurgen Klopp claimed the referee cost Liverpool a point at Old Trafford, but I wouldn't agree with him on this occasion", states Aldridge.
With Marouane Fellaini rejecting a new contract at United and Michael Carrick retiring at the end of the season, it would be understandable for Mourinho to look for reinforcements in the midfield.
To date, Rashford has earned 15 worldwide caps with England, scoring twice in the process - with his first coming three minutes into his debut against Australia in May 2016 - and creating two goals. It looks to be a tough ask, with the back four set to be reshuffled in the absence of Miguel Layun.
The decision to not go looking for an away goal against a side that has lost heavily to the likes of Spartak Moscow, Eibar and Real Betis this season will come back to haunt Mourinho if United fail to progress. We're still talking about it, to be honest, so there's nothing to totally confirm as yet.
Vincenzo Montella acknowledged Manchester United have the players to worry him and he expects his Sevilla side to face a "very offensive" opponent at Old Trafford on Tuesday.
Steven N'Zonzi of Sevilla in action with Marcus Rashford in the Round of 16 First Leg against Manchester United on 21 February 2018.
United, who will play its first Champions League knockout game in four years, has won 15 of the 18 home games so far this season. There was at Selhurst Park (United's 3-2 win over Crystal Palace) last week, and that spirit carried forward onto Saturday (2-1 win over Liverpool).
"When I say Liverpool, it is just to say that Sevilla is a really good team and the result of the first leg is a result that leaves everything open for tomorrow".
"Right now, I'm probably not learning the most on the pitch", Rashford said.