Plenty of tries but still plenty to work on for Ireland in the weeks break next week, before welcoming Wales here the week after.
Ireland are now on an nine-game winning streak and have won 12 of their last 14 matches.
But fans at least went home happy after a routine win in which five players - one starter and four replacements - got their first taste of the Six Nations.
"Tadhg is okay, It was precautionary, he was tight in the hamstring, he hadn't any problems during the week so we're hopeful that won't be anything that gets in the way of him potentially training a bit by Thursday next week and then getting into a full week of preparation the following week for Wales".
The outside centre bagged two tries today, but landed rather awkwardly when scoring the second.
The procession continued after the restart as Henshaw went over in the 44th minute but he sustained an arm injury in the process and was forced off to be replaced by 20-year-old Larmour.
"I think it is always nice when you get a compliment from an opposition captain, but ultimately we will look at this game and see there are a lot of things that we can do a lot better, especially in the second half", said Best.
It was a better performance from Schmidt's men following last weekend's 15-13 win over France, as centre Robbie Henshaw and left wing Jacob Stockdale both crossed for braces.
Stockdale soon had his second and Ireland's eighth before Italy grabbed a third late on through Matteo Minozzi.