The Manchester City striker fainted on Argentina duty and was rushed to hospital for tests. Kolarov, Bacary Sagna, Pablo Zabaleta, Fernando, Nolito and Jesus Navas all played in a City side that looked totally unfit for purpose.
Aguero has scored 10 goals in 12 appearances for Premier League leaders City this season and recently became the club's all-time leading goal-scorer after eclipsing Eric Brook's record of 177.
Manchester City manager Pep Guardiola hailed John Stones, but hopes the defender is ready to continue improving.
It is expected that Guardiola will have a full-strength squad to head to the Midlands.
"Defensively all the team helped a lot but he joined a good partnership with Nico [Otamendi]".
City have made an unbeaten start to the season and already sit eight points clear of second-placed Manchester United after 11 games.
The Spaniard took over at the Etihad in July 2016 on an initial three-year deal following silverware-laden spells in charge of Barcelona and Bayern Munich.
The Blues even started selling replica shirts with his name emblazoned on the back in their online club store.
When asked about wonderkid Phil Foden, Guardiola reiterated that the 17-year-old is part of his plans and will not be loaned out in January. They need five more wins to match Arsenal's 14-win sequence from 2002 and stand unbeaten in 23 so far, since last season's FA Cup semifinal defeat to Arsenal - and to resume where they left off before the international break. "Nothing to be worried about". But perhaps none of them will be as robust an examination as Leicester are likely to produce this weekend.
"You have a lot of skills and talent when you buy them but they have to live the situation to realise, 'OK, I can handle it'".