Wenger was dealt a blow when key centre-back Shkodran Mustafi was ruled out for several weeks with a thigh injury suffered on global duty with Germany, and fellow defender Laurent Koscielny faces a late fitness test.
Germany secured their place in Russian Federation after a 3-1 victory away to Northern Ireland but the reigning world champions still had to face Azerbaijan at the Fritz-Walter-Stadion on Sunday evening.
Speaking to ESPN about the centre-back, Wenger said, "I don't think he will be available before the next worldwide break".
Laurent Koscielny has been another injury worry of late with a recurrent Achilles problem, and Wenger confirmed that the centre-back will have a late fitness test, have recently stepped up individual training.
"The minor problem we have is with Sead Kolasinac. I will make a check up this morning, but the news we have on him is quite positive", Wenger added. "I am more concerned that yesterday afternoon I watched the whole game Brazil against Chile to see how hard was the game and I must say he got some special treatment in this game". This is going to be a testing game for them since Watford are a very well built team and they have shown that many times this season. "Mentally, I will have to assess the situation when he comes back tomorrow". The fact that we didn't find agreement previous year doesn't mean he wants to leave. "At the present time there is no deal close for me to announce".
He missed Arsenal's game against Brighton, and according to The Telegraph, he is yet to return to full training and could miss the trip to Vicarage Road as well.
Arsenal have enjoyed an impressive return to form since suffering a heavy defeat at the hands of Liverpool in August, as they are unbeaten in their last seven matches and they have kept clean sheets in their previous four league games.