In this strike, the missiles were aimed at IS command points, communication hubs and arms dumps southeast of the city of Deir el-Zour, where Syrian troops and allied militias are battling the extremists.
Philippine government forces have been trying to remove IS-linked militants from the city since May.
As IS continues to lose ground in Syria and Iraq, the extremists recently released a video encouraging fighters to join a campaign in the Philippines near the city of Marawi.
The Syrian Democratic Forces (SDF), a USA -backed alliance of mostly Arab and Kurdish fighters, meanwhile have also launched a separate assault in Deir al-Zor province, which has become Islamic State's last major foothold in Syria.
Aziz added that they are about 6 kilometers (4 miles) away from the city's eastern entrance.
While the evacuation, which was negotiated by Lebanon's Hezbollah group, removed the militants from the Syria-Lebanon border, it left both Iraq and the US fuming.
The deal reached at the end of August allowed hundreds of militants and their families to relocate to Boukamal, an Islamic State-held Syrian town near the Iraqi border, in exchange for Islamic State-held prisoners and the remains of Lebanese soldiers captured in 2014.
U.S. Army Colonel Ryan Dillon, a spokesman for the U.S. -led coalition fighting Islamic State, told reporters that the battlefield was already congested and the plan was for the SDF to move down the middle Euphrates River Valley.
The head of the Britain-based Syrian Observatory for Human Rights said buses and vehicles crossed into Deir el-Zour province Wednesday.